Dubai Weather – What You Should Know Before Traveling to Dubai

Dubai weather can be summed up in one word: "hot". It should come as no surprise though: Dubai is situated right at the edge of the middle east over a vast expanse of desert. Its abundance to the sea does not help the weather at all and only adds to the already excruciating humidity. In this article, we will explore Dubai weather and tell you which seasons are the best to visit Dubai.

For visitors coming in from colder climates, the best time to come to Dubai is between November and March, when it is the so called "winter" season here. During this season, the days are sunny and warm. In fact, most people end up falling absolutely in love with the Dubai weather during this season – there's plenty of sunlight, ample sand, and it seldom becomes unbearably hot. In terms of absolute temperature, it hovers around 23-25 ​​degrees Celsius during this time – a quite agreeable temperature for most people. The nights, however, are much cooler, bordering on chilly.

The summers are when the Dubai heat truly shows its colors. Temperatures routinely soar above 40 degrees (Celsius). The further you travel away from the sea, the hotter it becomes. The interior parts of Dubai are absolutely unbearable during the summers. If Dubai were not such a modern, air-conditioned city, it would've looked like a ghost town in the summers.

Of course, summer in Dubai does not mean that you have the luxury of walking around in shorts and spaghetti tops. Remember that Dubai, despite being a very modern city, is still very conservative. When you are here, please respect the local culture by dressing up more modestly, even in the summers.

Whether you are traveling to Dubai in the summers or the winters, you must take care to avoid a heatstroke or a sunburn. Keep yourself hydrated at all times and wear a strong sunscreen whenever you go out. If possible, avoid going out in the daytime.

The perks of visiting Dubai in the summer are cheaper rates at all hotels and resorts. This is the off-peak season and you will find some great deals everywhere. If you are a cost conscious traveler who can bear the heat, the summer might be a good time to visit this city-state.

Finally, remember that Dubai is air-conditioned almost everywhere. The people here like to turn up the air-conditioning. A traveler unaccustomed to the air-conditioning here can easily catch a cold. Therefore, always carry a jacket or sweatshirt with you, particularly if you are going to be inside an enclosed, air-conditioned space for a long time.

Preformulation and Formulation Development

Optimizing Conformational Stability and Biological ActivityMaintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate various various buffer, pH, ionic strength, and excipient conditions, and identify the conditions that confer the optimum environment for the therapeutic protein.

Utilizing Advanced Statistical Design for Preformulation Development Preformulation development includes statistical design of experiments, allowing simultaneous evaluation of multiple factors and evaluation of interactions between factors. It is crucial to use advanced biophysical characterization techniques to evaluate the conformational stability of large molecules in addition to traditional methods for evaluation of chemical stability.

A large molecule preformulation development program typically includes the following activities:
Evaluate the effect of pH, buffer type, and ionic strength on solubility.
Evaluate the effect of various excipients on improving solubility if necessary.
Evaluate effects of pH, buffer type, and excipients on conformational stability.
Evaluate the effect of pH, buffers, excipients and ionic strength on physical and chemical stability.
Utilize a statistical design approach to identify the optimal conditions for structural, physical and chemical stability.
Perform forced degradation to elucidate product degradation pathways and to demonstrate the stability-indicating capacity of the analytical methods.
Forced degradation studies typically include restricted oxidation, deamidation, aggregation (via agitation), and / or acid / base hydrolysis.
Evaluation of heat stress, photo stress, and freeze thaw are also performed.

Looking for information on Analytical Development and other related resources?

Formulation Development for Numerous Dosage FormsFormulation development includes dosage forms for parenteral, oral topical and inhalation administration, including liquids, gels, suspensions, emulsions and lyophilized powders. Formulation scientists are highly skilled in the development of the dosage forms most relevant to biotherapeutics, with particular expertise in lyophilization and development of stable liquid formulations for proteins. High concentration antibody formulation development for subcutaneous administration requires particular emphasis on viscosity and tonicity. Lyophilization cycle development is performed in the context of the unique thermodynamic properties of the API to deliver an efficient, scalable, transferable process resulting in optimum product stability and reconfiguration characteristics. Formulation development capabilities also include:

Effect of excipients on solubility, tonicity, and viscosity Evaluation of antioxidant and conservative compatibility Container-closure compatibility Long term and accelerated stability studies.

Advantages of Formulation Development Approach. This outlined approach to preformulation and formulation development result in significant savings to the client by eliminating the variables associated with suboptimal formulations. Preclinical development efforts in PK, PD, ADME and toxicology occur with confidence that additional uncontrollable variables from unstable formulations are not introduced into the study. This benefit extends far into clinical trials as well, where assessment of toxicity, dosage levels and efficiency are substantially influenced by an optimal formulation that preserves the three dimensional conformation of the therapeutic protein. By eliminating uncontrolled stability variables, the focus is placed solely on the therapeutic performance and clinical outcome.

5 Deadly Financial Mistakes You Should Avoid Now To Keep Out Of Debt Later!

Every year more families are going to the brink of financial ruin because they never properly considered their financial future. For some, it's just to stressful or emotionally uncomfortable to think about and important financial decisions get put off indefinitely. For many, they do not know and were never taught some basic financial planning tips to keep them out of debt in the future. Here are five financial mistakes you should avoid now to keep your financial future bright:

5 Financial Mistakes To Avoid:

1. Buying on credit: Today's interest rates are fairly low, but this does not mean you should buy excessively on credit! Carrying a large balance on credit cards month to month is a recipe for disaster. Finance charges alone can slowly eat you up. Buying a car on credit ties up even more of your future earnings for debt repayment.

Just a few decades ago buying so much on credit was unheard of. Children were taught early on what a huge mistake this was. We all need to relearn this lesson and eliminate buying on credit to keep ourselves out of debt

2. Making financial decision based on emotion: When you are going through great stress or emotional turmoil you are most vulnerable to making disastrous financial financial decisions. It is when you are feeling some king of pressure that you are most likely to make silly decisions that get you into trouble later. Do not make a big money decision when you are emotionally vulnerable.

3. Not adequately insuring against catastrophic risk: Every year families are financially devastated because they are not protected against disaster. Loss of home and assets to fire and flood are very common events that a surprising number of people do not protect against with insurance. You should also protect against disaster common to your area. Earthquakes and tornadoes for example. Just as important is some kind of life insurance to protect your loved ones in case of death.

4. Falling for the slick salesmen pitch: They say a sucker is born every minute. And you can be sure there is a slick salesmen waiting to take advantage of every one of them! You should never enter into any financial decision based on salesmen pressure tactics or one-time offers. Great deals that can not wait for you to think on it or obtain a second opinion are often financial disasters waiting to happen.

5. Not planning out your financial future: For many people it is so much easier to put off the tough financial planning right now and get to it someday in the future. Well we know how that story goes. Years into the future many families are neck deep in debt with no relief in sight. And it could of all been avoided with some sensible planning. Talk to a financial planner today so you can be debt free tomorrow!

There you have it. Five important financial mistakes to avoid so you can be both debt and worry free in your future. No matter where you are at right now financially, it's not to late to get started. Make an appointment with a financial planner today and get your financial future properly planned out. It's one of the most important things you can do for your family and for yourself.

Reasons For Pregnant Women to Wear Maternity Clothes

For many women, pregnancy is a very exciting and exciting time in their lives. Through the pregnancy period, a woman undergoes many physical and emotional changes. When a woman begins to gain weight, she can experience physical discomfort as well as feeling less attractive. The inability to wear one's regular clothes can result in frustration and sadness. The importance of wearing maternity clothing is essential to making a woman look and feel good through the entire term of her pregnancy.

When one thinks of maternity clothing, they often think about drab, unattractive, and baggy clothes. Fortunately, there are maternity clothes on the market that are designed to display quality, comfort, durability, and fashion. There are hundreds of online retailers and traditional 'brick and mortar' stores that sell quality and comfortable maternity clothing.

Physical changes an expectant will include include: gain in weight, larger abdomen, and swollen ankles and fingers. Many maternity clothing providers understand the need for a comfortable pair of maternity pants. Many maternity pants can be worn through or nearly all of the pregnancy term. Maternity pants are available in a wide range of colors, styles, designs, and patterns. They can even include jeans with stretchable waist bands. Maternity pants are sold in a broad range of styles and comfort levels. The stretchable elastic waist bands allow an expectant mother to relax. As well, there are pants that are designed to give a slimming effect.

A pregnant woman can still wear stylish brand name dresses. There are maternity dresses for any time of social setting such as at a formal function or just relaxing around the house. One can wear sun dresses, short-sleeved dresses, long-sleeved dresses, strapless dresses, casual dresses, short dresses, or full length dresses. They come in many styles, colors, designs, and patterns. They are designed to make a woman feel comfortable and feminine, while looking fashionable and they take a maternity photography.

Maternity tops can come in a variety of designs, styles, and colors. These tops are comfortable and fit well to the growing abdomen. They are deigned for current and changing fashion trends. They will make a woman feel attractive as she increases in weight.

Swimwear is another popular form of maternity wear. Popular maternity stores that offer maternity swimwear include: bikinis, one piece suits, and bathing suit bottoms. A pregnant mother can enjoy herself sunbathing or swimming. There are a range of maternity swimwear companies that sell swimwear designed by top selling brands.

A pregnancy does not mean one has to wear dismal clothing. There are many top brands that sell chic and trendy maternity clothing such as Old Navy Maternity, Motherhood Maternity, Gap Maternity, and much more. Wearing trendy and stylish maternity clothing through a pregnancy can make a woman comfortable and attractive, thereby allowing her to focus on the arrival of her new bundle of joy.

An expectant mother's pregnancy does not have to have a time of discomfort and feeling unattractive. There are now many popular brand name maternity wear companies that sell a variety of stylish and comfy clothing to meet the needs of every expectant mother.